Isabelle suddenly ages into womanhood, and Richard is horrified to learn that the effect has caused Lily to become an old woman. Meanwhile, T.J. Kim, now a member of the terrorist Nova Group, uses her ability to nearly kill Dennis Ryland at a Congressional hearing.

Isabelle suddenly ages into womanhood, and Richard is horrified to learn that the effect has caused Lily to become an old woman. Meanwhile, T.J. Kim, now a member of the terrorist Nova Group, uses her ability to nearly kill Dennis Ryland at a Congressional hearing.

A shape-shifting member of the Nova Group kills T.J. Kim while in the guise of Tom. Meanwhile, Shawn helps Isabelle to achieve rites of passage that she missed.

Maia, along with other 4400 children, is kidnapped, forcing Diana to look through Maia's diaries for clues. Meanwhile, Richard, after learning that Shawn donated money to the Nova Group, tries to convince Shawn to let him share power at the 4400 Center.

Although all evidence and memories of Maia, as well as other 4400 children, have been wiped from existence, Tom and Diana have recurring thoughts of her. With Alana's help, Diana manages to regain her memories, but how can they possibly rescue the 4400 children, who have been sent farther back in time?

As Isabelle retaliates against the Nova Group for attacking Shawn, Alana learns the identity of the drunk driver that killed her husband and son.

NTAC finally locates Gary Navarro, but someone at the 4400 Center tips him off before they can catch him. Meanwhile, Nikki Hudson visits Shawn and asks that he heal her father, who has cancer. After Shawn does, Nikki invites Shawn to dinner, which makes Isabelle jealous.

Tom and Diana are drugged with a hallucinogen, created by a 4400, that causes them to confront significant people from their pasts.

Kevin runs for his life when he becomes a marked man because of his promicin research; and as Tom and Diana search for him, they discover the depths of his devotion to his work. Also, Shawn meets his idol at the 4400 Center.

As a wedding present, a 4400 gives Shawn a cigar that will allow him to see the future. Shawn uses it but has visions of the gruesome results of both marrying and not marrying Isabelle. Meanwhile, Tom and Diana try to find a killer that has somehow gained a 4400 ability.

Hoping to get Kyle freed from prison, Tom searches for Jordan Collier to prove that he is still alive. Meanwhile, Diana's sister April returns and reveals that she is moving to Seattle with her new boyfriend. However, Maia then has a vision in which Diana, not April, marries him.

At the 4400 Center, Jordan gives a press conference about his a resurrectiona and a war between good and evil that supposedly already began. Tess and Kevin are still fugitives at large and Jordan enlists a 4400 who has a remote viewing ability to track down the duo. Isabelle and Ryland meet againa Boyd Gelder resurfaces.

Through an online video, Devon reveals to the world that she is going to start injecting herself with Promicin and that it will be available to the public soon. However, her body later rejects the Promicin, and Shawn is captured by NTAC while he tries to heal her. He refuses to tell where the Promicin is being held, but Isabelle manages to get the information from him. Predicting that she would find the location, Collier takes the Promicin from the warehouse and plants a bomb. However, Isabelle survives and decides that the only way to draw out Collier is to attack the 4400 Center.